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Effect of carboxamide derivatives of compound 1 on Sirt6 myristoylated activity.
| |||
|---|---|---|---|
| Cmpd | R = Carboxamides derivatives |
R1 = | Inhibition c = 10 μM |
| 4 |
|
|
29% |
| 5 |
|
|
1% |
| 6 |
|
|
34% |
| 7 |
|
|
1% |
| 8 |
|
|
38% (IC50 = 26 μM)[a] pIC50 (4.6 ± 0.1) |
| Nicotinamide (1000 μM) | 92% | ||
Based on an inhibition curve ending with 60% inhibition at 50 μM compound; higher concentrations not tested.
