Table 4.
Multivariate analysis including clinicopathological and molecular variables and their impact on PFS
| PFS | Multiple analysis | Shrunked | |||
|---|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | ||
| PD-L1 | Negative | Ref | Ref | ||
| Positive | 0.44 (0.28, 0.70) | 0.0001 | 0.48 (0.31, 0.77) | 0.0017 | |
| cfDNA at T1 | <8.11 | Ref | Ref | ||
| ≥8.11 | 1.65 (1.06, 2.59) | 0.0272 | 1.57 (1.01, 2.47) | 0.0480 | |
| cfDNA ∆T2–T1 | <−0.11 | Ref | Ref | ||
| ≥−0.11 | 1.98 (1.27, 3.08) | 0.0025 | 1.84 (1.18, 2.86) | 0.0070 | |
| VAF at T2 | <1.94 | Ref | Ref | ||
| ≥1.94 | 2.74 (1.75, 4.29) | 0.0000 | 2.46 (1.57, 3.85) | 0.0001 | |
| C-index | 0.718 | 0.707 |