Table 5.
Multivariate analysis including clinicopathological and molecular variables and their impact on OS
| OS | Multiple analysis | Shrunked | |||
|---|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | ||
| PD-L1 | Negative | Ref | Ref | ||
| Positive | 0.44 (0.28, 0.70) | 0.0001 | 0.50 (0.31, 0.79) | 0.0032 | |
| Histology | Non-squamous | Ref | Ref | ||
| Squamous | 3.05 (1.60, 5.83) | 0.0001 | 2.59 (1.35, 4.94) | 0.0040 | |
| cfDNA at T1 | <8.33 | Ref | Ref | ||
| ≥8.33 | 1.67 (1.05; 2.65) | 0.0308 | 1.50 (0.98; 2.47) | 0.0631 | |
| cfDNA ∆T2–T1 | <3.43 | Ref | Ref | ||
| ≥3.43 | 1.88 (1.19, 2.98) | 0.0067 | 1.71 (1.08, 2.71) | 0.0211 | |
| maxVAF at T2 | <1.94 | Ref | Ref | ||
| ≥1.94 | 2.74 (1.74, 4.33) | 0.0001 | 2.36 (1.50, 3.72) | 0.0002 | |
| C-index | 0.740 | 0.726 |