Table 2.

Treatment-related adverse events and serious adverse events.

Adverse events	Any grade	Grade 1	Grade 2	Grade 3	Grade 4–5
Any	10 (100%)	8 (80%)	5 (50%)	3 (30%)	0
Hypertension	8 (80%)	8 (80%)	0	0	0
Elevated transaminases	6 (60%)	5 (50%)	1 (10%)	0	0
Diarrhea	5 (50%)	2 (20%)	2 (20%)	1 (10%)	0
Thrombocytopenia	5 (50%)	3 (30%)	2 (20%)	0	0
Elevated bilirubin	4 (40%)	3 (30%)	1 (10%)	0	0
Fatigue	3 (30%)	0 (0)	2 (20%)	1 (10%)	0
Pruritus	2 (20%)	0	1 (10%)	1 (10%)	0
Proteinuria	2 (20%)	0	2 (20%)	0	0
Neutropenia	2 (20%)	1 (10%)	1 (10%)	0	0
Pneumonitis	2 (20%)	1 (10%)	1 (10%)	0	0
Abdominal pain	2 (20%)	1 (10%)	1 (10%)	0	0
Elevated pancreatic enzymes	2 (10%)	2 (10%)	0	0	0
Elevated creatinine	2 (20%)	2 (20%)	0	0	0
Anemia	1 (10%)	1 (10%)	0	0	0

Data are n (%) and represent the highest grades assigned.