Figure 3.

Forest plot comparing the risk of treatment failure in patients with Staphylococcus aureus native vertebral osteomyelitis (NVO) treated with adjunctive rifampin or not, stratified by methicillin resistance. Methicillin resistance status did not significantly modify the effect of adjunctive rifampin compared with standard of care on the risk of clinical failure (P = .3). There is no significant heterogeneity between study results within each subgroup that require further exploration. However, a smaller number of studies and patients contributed data to the methicillin-resistant S. aureus (3 studies, 52 patients) compared with the methicillin-susceptible S. aureus (7 studies, 383 patients); therefore, the analysis may not be able to detect subgroup differences. Abbreviations: CI, confidence interval; M-H, Mantel-Haenszel; MRSA, methicillin resistant Staphylococcus aureus.