Table 1.
Species | Reference | Imaging modality | Imaging target |
Use in Chakraborty et al. | Strain | Age (y or m) | Sex (M:F) |
---|---|---|---|---|---|---|---|
Human | HCP | 7 T MRI | White matter fiber bundles | Gradient calculation, residual analysis (Figs. 2–8 and Supplementary Fig. S1–S6) | N/A | 22-35 y | 69:104 |
Resting-state BOLD signal | |||||||
Human | Kanel | PET | [18F]FEOBV | Principal correlation analysis of structure-function tethering and cholinergic innervation (Figs. 4, 8) | N/A | 24.5 (4.9) y | 10:3 |
Human | Aghourian | PET | [18F]FEOBV | Replication correlation analysis of structure-function tethering and cholinergic innervation (Supplementary Fig. S5) | N/A | 66.8 (6.8) y | 5:13 |
Human | Bedard | PET | [18F]FEOBV | Replication analysis of structure-function tethering and cholinergic innervation (Supplementary Fig. S5) | N/A | 68.3 (3.1) y | 4:1 |
Human | Tuominen | PET | [18F]FEOBV | Replication analysis of structure-function tethering and cholinergic innervation (Supplementary Fig. S5) | N/A | 37 (10.2) y | 3:1 |
Mouse | Li (SI Appendix Fig, 7) | fMOST | AAV-CAG-flex-GFP | Unimodal versus transmodal cholinergic neuron branch counts with retrospective mouse data (Fig. 7 and Supplementary Fig. S7) | ChAT-ires-Cre | 3 m | N/A |
Mouse | N/A | microPET | [18F]FEOBV | Cross-validation of human cortical cholinergic innervation with prospective mouse data (Fig. 7 and Supplementary Fig. S7) | VAChTflox/flox | 6 m | 3:3 |
Cross-validation of human cortical cholinergic innervation with prospective mouse data (Fig. 7 and Supplementary Fig. S7) | C57BL/6 J | 2:3 |
fMOST fluorescence micro-optical sectioning tomography, y years, m months, M male, F female. Ages are given as mean SD, where applicable.