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. 2024 Oct 17;15:8979. doi: 10.1038/s41467-024-53454-4

Fig. 7. Phage diversity during maintenance therapy or withdrawal.

Fig. 7

LOTUS vOTUs that were classified as a virus (n = 25941) were included in the analysis. A Effect of low dose maintenance FMT (n = 4 patients) or withdrawal (flare, n = 4 patients) on Margalef’s (species) richness in the LOTUS trial. Differences were tested with a two-way repeated measures ANOVA and multiple comparisons testing was performed using an uncorrected Fisher’s LSD. B Principal coordinate analysis (PCO) on Aitchinson distances for LOTUS samples across all groups. Differences between groups were tested using PERMANOVA and PERMDISP. FMT_i: patients at end of induction FMT therapy that went into maintenance arm, FMT_m: patients at end of maintenance FMT therapy, Flare_i: patients at end of induction FMT therapy that went into withdrawal arm, Flare_m: patients who withdrew from therapy around the time of disease flare. C vOTUs that had significantly altered relative abundances during maintenance FMT or withdrawal (n = 4 patients sampled before and after for each group). Only LOTUS vOTUs with homology to vOTU_151 in FOCUS were tested. vOTU_2578 and vOTU_3315 were associated with response at induction. Differences were tested with a two-way repeated measures ANOVA and multiple comparisons testing was performed using an uncorrected Fisher’s LSD. Source data are provided as a Source Data file.