Table 3.
Phenotypic comorbidity network structures in subgroups of patients with thyroid disease.
| Subgroup | Nodes, n | Density | Degree, median (IQR) | Degree of neighbors, median (IQR) |
|
||||||
| MIMICa-IV | Private | MIMIC-IV | Private | MIMIC-IV | Private | MIMIC-IV | Private | ||||
| All | 102 | 72 | 0.321 | 0.192 | 30.0 (20.0-46.0) | 9.0 (6.0-17.5) | 49.2 (44.0-54.9) | 28.3 (23.1-34.4) | |||
| Sex |
|
|
|
|
|
|
|
|
|||
|
|
Female | 90 | 60 | 0.312 | 0.240 | 27.0 (18.0-40.0) | 11.5 (6.0-16.0) | 43.0 (36.7-46.3) | 26.7 (21.3-30.7) | ||
|
|
Male | 92 | 63 | 0.229 | 0.304 | 17.0 (10.8-27.8) | 14.0 (10.0-22.0) | 38.7 (33.2-43.0) | 32.9 (28.8-39.4) | ||
| Disease subgroup |
|
|
|
|
|
|
|
|
|||
|
|
TCb | 28 | 15 | 0.087 | 0.419 | 1.5 (1.0-2.0) | 4.0 (3.5-5.5) | 24.2 (16.5-31.0) | 11.0 (8.8-12.2) | ||
|
|
BTDc | 100 | 69 | 0.338 | 0.198 | 30.0 (21.5-46.0) | 10.0 (6.0-16.0) | 48.4 (42.9-52.7) | 28.3 (23.6-34.6) | ||
|
|
Nontoxic goiter | 81 | 65 | 0.111 | 0.217 | 6.0 (2.2-9.8) | 10.0 (6.0-15.0) | 31.2 (24.7-46.7) | 30.9 (22.2-34.0) | ||
|
|
Hypothyroidism | 100 | 61 | 0.329 | 0.237 | 29.0 (20.0-43.0) | 11.0 (7.0-17.0) | 47.0 (41.4-51.8) | 28.2 (23.3-33.7) | ||
|
|
Hyperthyroidism | 79 | 39 | 0.098 | 0.208 | 4.0 (2.0-9.2) | 5.0 (3.0-8.0) | 30.8 (21.6-46.1) | 23.0 (18.6-29.8) | ||
| Age group (years) |
|
|
|
|
|
|
|
|
|||
|
|
18-39 | 57 | 46 | 0.115 | 0.133 | 6.0 (2.0-9.0) | 4.0 (3.0-6.0) | 11.9 (10.0-14.3) | 21.1 (15.8-29.7) | ||
|
|
40-49 | 71 | 55 | 0.127 | 0.143 | 7.0 (4.0-15.2) | 5.0 (3.0-7.0) | 17.5 (14.6-20.1) | 27.0 (22.6-33.0) | ||
|
|
50-59 | 85 | 66 | 0.171 | 0.207 | 12.0 (6.0-21.0) | 9.5 (6.0-14.0) | 25.7 (23.0-30.1) | 33.7 (26.7-39.1) | ||
|
|
60-69 | 92 | 65 | 0.206 | 0.265 | 17.0 (9.0-25.5) | 12.0 (8.0-19.0) | 34.6 (29.2-39.5) | 35.7 (28.9-42.6) | ||
|
|
≥70 | 89 | 59 | 0.265 | 0.353 | 22.0 (10.0-35.0) | 15.0 (11.0-22.5) | 39.2 (33.9-43.5) | 38.2 (32.0-41.2) | ||
aMIMIC: Medical Information Mart for Intensive Care.
bTC: thyroid cancer.
cBTD: benign thyroid disease.