Table 1.
The characteristics of the 53 RCTs.
| Published Year |
Published Country |
Type of Antimicrobial in Beta-Lactam Monotherapy Arm | Type of Antimicrobial in Beta-Lactam + AG Arm |
Type of Beta-Lactam between Same Beta-Lactam and Beta-Lactam + AG (16) |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1983–1989 | 10 | Turkey | 7 | MEPM | 11 | IMP/CS + AG | 1 | Carbapenem | 1 | CAZ or Carbapenem | 1 |
| 1990–1999 | 23 | USA | 6 | IMP/CS | 11 | CFPM + AG | 4 | beta-lactam/beta-lactamase inhibitor | 4 | CPZ | 1 |
| 2000–2009 | 15 | Germany | 4 | IMP/CS or MEPM |
1 | CPZ/SBT + AG | 4 | CFPM | 3 | ||
| 2010–2019 | 5 | Japan | 3 | PIPC/TAZ | 6 | CAZ + AG | 23 | CAZ | 6 | ||
| UK, Australia, Belgium, Netherlands, Mexico, Chile, India |
2 | CAZ | 11 | CAZ or IMP/CS + AG | 1 | type of beta-lactam between different beta-lactam and beta-lactam + AG (37) |
|||||
| other | 19 | CFPM | 8 | carbenicillin + AG | 1 | Carbapenem | 22 | beta-lactam/ beta-lactamase inhibitor + AG |
6 | ||
| CAZ or IMP/CS | 1 | azlocillin + AG | 2 | beta-lactam/ beta-lactamase inhibitor |
4 | CAZ + AG | 17 | ||||
| CPZ/SBT | 2 | CPZ + AG | 1 | CFPM | 5 | CAZ + AG or CFPM + AG | 1 | ||||
| CPZ | 1 | PIPC/TAZ + AG | 6 | CAZ | 5 | PIPC/AZL/CAR/TIPC + AG | 13 | ||||
| PIPC | 1 | PIPC + AG | 9 | PIPC/AZL/CAR/TI‘C | 1 | ||||||
| ticarcillin + AG | 1 | ||||||||||
Abbreviations: MEPM, meropenem; IMP/CS, imipenem/cilastatin; PIPC/TAZ, piperacillin/tazobactam; CAZ, ceftazidime; CFPM, cefepime; CPZ/SBT, cefoperazone/sulbactam; AG, aminoglycoside.