Figure 2.

Comparing lung injury scores between ischemic and control lungs in the unilateral pulmonary IRI mouse model - treatment with Hx. Lung tissue damage in the applied mouse model of unilateral pulmonary IRI was evaluated according to the lung injury score by Murakami et al. (22). In this scoring system, lung injury was graded on a scale of 0 to 4 (0, normal; 1, light; 2, moderate; 3, strong; 4 intense) for congestion, edema, infiltration, and hemorrhage in multiple areas (10 microscopic view fields). The left ischemic lung (IRI) exhibited significantly higher levels of lung injury than the right control lung (Con) (IRI vs. Con: 9 (6) vs. 2 (2), respectively: p = 0.02, IRI vs. Sham: 9 (6) vs. 0 (0), respectively: p = 0.008). Moreover, in the group of mice treated with Hx (IRI group vs. Hx treated group: 9 (6) vs. 5 (1.5), respectively: p = 0.037). (n=5 mice in each group). N.S., not significant.