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. 2024 Oct 4;15:1451577. doi: 10.3389/fimmu.2024.1451577

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Copyright © 2024 Nakagiri, Köhler, Janciauskiene, Neubert, Knöfel, Pradhan, Ruhparwar, Ius and Immenschuh

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hx alleviates intravascular thrombus formation in the ischemic lung of the unilateral pulmonary IRI mouse model. Histological studies revealed significantly higher numbers of thrombotic blood vessels in the left ischemic compared to the right control lung (72.5 (15.6)% vs. 0 (8.1)%, respectively: p = 0.008). The number of thrombotic pulmonary vessels was significantly reduced in the group of mice treated with Hx (IRI group vs. Hx treated group: 72.5 (15.6)% vs. 34.7 (33.7)%, respectively: p = 0.008). n=5 mice for each group. N.S., not significant.