Table 1. Efficacy in Dose-Dependent Cell Survival and Cell-Surface Binding^a.

receptor	compound	EC50 (μM)	EC50 (μM) with suboptimal neurotrophin	Kd (nM) for cell surface
TrkA	5a(iii)m	2.4	0.5	120 ± 3
	5c(ii)	4.5	0.3	91 ± 2
TrkB	5b(i)	0.4	1.8	73 ± 13
	5b(ii)	0.9	2.8	115 ± 66
	5c(i)	0.1	2.2	43 ± 2
TrkC	5c(i)	3.3	4.9	97 ± 4
	5c(iii)	0.8	0.9	91 ± 4

^aSuboptimal NT concentrations were 0.2 nM NGF, 0.6 nM BDNF, and 0.2 nM NT-3 for TrkA-, B-, and C-expressing cell lines, respectively. Survival data was normalized relative to DMSO (0% survival) and optimal neurotrophin (2.0 nM NGF, 1.0 nM BDNF, 2.0 nM NT-3; 100% survival). EC₅₀ values were calculated using the nonlinear regression “{agonist} vs response – Variable slope (four parameters)” analysis, and K_d’s were calculated by first subtracting nonspecific binding, then using the nonlinear regression “One site – specific binding” analysis in GraphPad Prism 10.2.