Figure 2.

Effects of the codissolved CFN (triangles), TPH (diamonds), TBR (squares), and XAT (crosses) in the IBP or DCF equimolar mixtures in the IBP (a) and DCF (b) dissolutions. Dissolution curves were fitted using the Noyes–Whitney equation with the dissolution rate constant term kS, in which the solid surface area parameter S was assumed to be invariable in dissolution to the equilibrium. The codissolved CFN and TPH decreased and increased the saturated concentrations of IBP and DCF, respectively. TBR and XAT exhibited limited influence on their solubility. (c) Effects of CFN and TPH codissolved proportions in the IBP mixtures on the IBP dissolutions. The codissolved CFN and TPH at the equimolar and double proportions attenuated the saturated concentrations of IBP; however, those at the half equivalences were ineffective. An equivalent or higher amount of CFN and TPH restricted the release of IBP from its solid phase.