FIGURE 5.

(a) X‐ray structure of the VHH2‐NKp30 complex (PDB code 9FWW). (b) Visualization of VHH2 paratope residues (within 4.5 Å of NKp30). (c) Depiction of an intramolecular interaction between Hallmark residue Phe42 and CDR3 residue Tyr115 that seems essential for positioning CDR3 in its bioactive conformation. (d, e) visualize a network of hydrophobic residues between Val25, Ile39 and Val87 that seem to be essential to position CDR2 in the bioactive conformation. Key residues that were subjected to humanization are indicated in the same color coding as in Figure 1.