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. 2024 Oct 18;22:634. doi: 10.1186/s12951-024-02890-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 5 — RNA sequencing analysis of NPCs with SeNPs intervention. A Heatmap of differentially expressed gene between control group and SeNPs intervention group. B GO enrichment analysis of biological processes and cellular component illustrated the count of the up- and down-regulated genes (indicated by the lines). C KEGG analysis revealed the up and down-regulated signaling pathways in NPCs. D, E, F GSEA enrichment analysis of glutathione transferase activity (p = 0.0024), glutathione peroxidase activity (p = 0.013), and response to selenium ion (p = 0.007) between the control and SeNPs groups