Table 5. Univariate and multivariate cox proportional hazard regression model for factors associated with the composite endpoint of aortic valve replacement and death.

	Univariate model		Multivariate model
	HR (95% CI)	P value	HR (95% CI)	P value
Age, per year increase	1.02 (1.01 to 1.03)	<0.001	1.03 (1.01 to 1.05)	0.003
Female sex	0.80 (0.55 to 1.16)	0.226	0.88 (0.59 to 1.30)	0.515
Bicuspid aortic valve	0.73 (0.49 to 1.08)	0.099	1.43 [0.78 to 2.63)	0.245
AA diameter	1.01 (0.98 to 1.05)	0.413	1.00 (0.97 to 1.04)	0.830
Fast progression of AA dilation	0.84 (0.61 to 1.15)	0.271	0.91 (0.65 to 1.25)	0.550

Fast progression of AA dilation=annualised progression above 0.18 mm/year. Values in bold reach statistical significance (p<0.05).

AAascending aorta HRhazard ratio