Fig. 3.

Inspiratory capacity at isotime and exercise endurance time during constant work rate cycle ergometry at Week 3 – adjusted mean differences between treatments (intention-to-treat set). The p values for BDP/FF/G vs. BDP/FF isotime inspiratory capacity and all exercise endurance comparisons are considered nominal only, given Step 4 of the hierarchy (BDP/FF vs. placebo for isotime inspiratory capacity) was not formally achieved. Inspiratory capacity data available from 92, 95 and 92 patients with BDP/FF/G, BDP/FF and placebo, respectively; exercise endurance time data available from 95, 96 and 95 patients, respectively. BDP, beclometasone dipropionate; FF, formoterol fumarate; G, glycopyrronium. The comparisons between BDP/FF/G and BDP/FF (i.e., the last row of the figure) are exploratory endpoints