Table 4.
Hematology on peripheral blood. RBC: red blood cells; WBC: white blood cells. *: pVal<0.01 vs Vehicle; #: pVal<0.01 vs 109 EVs. Reference values for C57BL/6 mice are reported in Supplementary Table 2.
| Hematology on peripheral blood - 24h | Hematology on peripheral blood - 10 days | |||||
|---|---|---|---|---|---|---|
| Parameters | Vehicle | 3.3E09 EVs/Kg | 3.3E10 EVs/Kg | Vehicle | 3.3E09 EVs/Kg | 3.3E10 EVs/Kg |
| Hemoglobin (g/dL) | 10.66 ±1.48 | 10.91 ±1.01 | 12.09 ± 0.45 | 10.14 ± 1.11 | 11.90± 0.21 | 10.60± 1.32 |
| Mean corpuscular hemoglobin (pg) | 15.20 ± 0.35 | 14.78 ±0.32 | 14.65 ± 0.32 | 14.77 ± 0.32 | 14.70± 0.17 | 15.56 ± 0.39 |
| Mean corpuscular hemoglobin concentration (g/dL) | 34.34 ± 53.07 | 32.91± 1.03 | 32.75 ± 0.47 | 33.88 ± 0.84 | 33.01 ± 0.48 | 33.95 ± 0.99 |
| RBC (106/μl) | 7.17 ± 1.01 | 7.46 ± 0.77 | 8.25 ± 0.31 | 6.65 ± 0.77 | 8.08 ± 0.13 | 6.96 ± 0.90 |
| WBC (103/μl) | 5.36 ± 1.03 | 4.19 ± 0.56 | 5.23 ± 0.91 | 8.06 ± 2.91 | 5.85 ± 0.73* | 4.08 ± 1.07* |
| Neutrophils% | 9.34 ± 1.64 | 10.01± 2.20 | 9.24 ±1.07 | 6.42 ± 1.78 | 14.96 ± 6.03# | 4.97 ± 0.55 |
| Eosinophils% | 1.21 ± 0.19 | 1.43 ± 0.32 | 1.16± 0.22 | 1.09 ± 0.14 | 1.43± 0.22 | 1.02 ± 0.24 |
| Basophils% | 0.55 ± 0.20 | 0.33 ± 0.14 | 0.24± 0.09 | 0.20 ± 0.08 | 0.23± 0.08 | 0.34 ± 0.13 |
| Lymphocytes% | 82.33 ± 1.93 | 77.86 ± 1.88 | 78.54± 2.38 | 79.93 ± 4.65 | 73.53 ± 6.37 | 79.89 ± 3.31 |
| Monocytes% | 9.56 ± 1.53 | 10.38 ± 1.51 | 10.81± 2.18 | 12.35 ± 3.52 | 9.85 ± 2.07 | 8.79 ± 3.59 |
| Platelet (103/μl) | 211 ± 126 | 213 ± 57 | 210 ± 58 | 216.25 ± 49.86 | 412.14 ± 248.79 | 273.88 ± 72.28 |