Fig. 6.

Circulating plasma EVs hsa_circ_0008362 was correlated with arterial calcification in patients with DM. A–C CT images showed the coronary artery calcification as well as aorta artery calcification and quantified as CACs and AACs in normal control and DM group (n = 20). D The relative expression of hsa_circ_0008362 was detected by qRT-PCR in plasma EVs of normal control and patients with DM (n = 20). E–H Correlations between circ_0008362 of plasma EVs and CACs as well as AACs were analyzed using a Spearman’s correlation analysis in normal control and patients with DM (n = 20). The normality of data distribution was assessed by Shapiro–Wilk test and Non-parametric Mann–Whitney U test for C and D. ****p < 0.0001, ***p < 0.001. ns, no significance; DM, diabetes mellitus; CACs, coronary artery calcification scores; AACs, aorta artery calcification scores