Fig. 2.

Mean Difference in Health Measures Between ME/CFS Participants With and Without Individual COPCs. Matrix graphs of health measures (A-G) by COPC comorbidities. Rows give the mean difference in specific subscale scores for ME/CFS participants with and without COPC in the column. SF-36 = 36-item Health Survey - Short Form [35]; PROMIS = Patient-Reported Outcomes Measurement Information System [29–34]; CDC-SI = CDC Symptom Inventory [26]; MFI-20 = 20-item Multidimensional Fatigue Inventory [27, 28]; BPI = Brief Pain Inventory [25]; CDC-HRQoL Unhealthy days [36]; cMHA = chronic migraine/headache; FM = fibromyalgia; cLBP = chronic low back pain; IBS = irritable bowel syndrome; TMD = temporomandibular disorder; IC/IB = interstitial cystitis/irritable bladder; COPCs = chronic overlapping pain conditions ^ap < 0.05, ^bp < 0.01, ^cp < 0.001, ^dp < 0.0001