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. Author manuscript; available in PMC: 2024 Oct 18.
Published in final edited form as: Arthritis Care Res (Hoboken). 2020 Jan 6;72(2):149–162. doi: 10.1002/acr.24131

Table 2.

Recommendations for the pharmacologic management of osteoarthritis of the hand, knee, and hip

Intervention Joint
Hand Knee Hip
Topical nonsteroidal antiinflammatory drugs
Topical capsaicin
Oral nonsteroidal antiinflammatory drugs
Intraarticular glucocorticoid injection
Ultrasound-guided intraarticular glucocorticoid injection
Intraarticular glucocorticoid injection compared to other injections
Acetaminophen
Duloxetine
Tramadol
Non-tramadol opioids
Colchicine
Fish oil
Vitamin D
Bisphosphonates
Glucosamine
Chondroitin sulfate
Hydroxychloroquine
Methotrexate
Intraarticular hyaluronic acid injection (First carpometacarpal)
Intraarticular botulinum toxin
Prolotherapy
Platelet-rich plasma
Stem cell injection
Biologics (tumor necrosis factor inhibitors, interleukin-1 receptor antagonists)
Strongly recommended
Conditionally recommended
Strongly recommended against
Conditionally recommended against
No recommendation