Table 2.

Treatment-related Adverse Events of Patients in the Intention to Treat Population

Characteristics	EA (n = 39)		Control Group (n = 19)		P

	Any Grade	Grade 3-4	Any Grade	Grade 3-4	Any Grade	Grade 3-4
Any adverse event	37 (94.87%)	6 (15.38%)	19 (100%)	6 (31.58%)	1.000^a	0.153^b
Leukopenia	19 (48.72%)	0 (0%)	10 (52.63%)	3 (15.79%)	0.780^b	0.031 ^a
Neutropenia	22 (30.77%)	1 (2.56%)	13 (68.42%)	5 (26.31%)	0.380^b	0.012 ^a
Thrombocytopenia	7 (17.95%)	0 (0%)	2 (10.53%)	0 (0%)	0.703^a	-
Anemia	14 (35.90%)	0 (0%)	9 (47.37%)	0 (0%)	0.402^b	-
ALT/AST increased	11 (28.21%)	0 (0%)	9 (47.37%)	0 (0%)	0.150^b	-
Bilirubin increased	2 (5.13%)	0 (0%)	0 (0%)	0 (0%)	1.000^a	-
Creatinine increased	1 (2.56%)	0 (0%)	0 (0%)	0 (0%)	1.000^a	-
Nausea	28 (71.79%)	3 (7.69%)	14 (73.68%)	1 (5.26%)	0.880^b	1.000^a
Vomiting	13 (33.33%)	3 (7.69%)	10 (52.63%)	2 (10.53%)	0.159^b	1.000^a
Diarrhea	16 (41.03%)	2 (5.13%)	4 (21.05%)	0 (0%)	0.155^a	1.000^a
Constipation	2 (5.13%)	0 (0%)	1 (5.26%)	0 (0%)	1.000^a	-
Oral mucositis	3 (7.69%)	0 (0%)	0 (0%)	0 (0%)	0.544^a	-
Foot-hand syndrome	8 (20.51%)	0 (0%)	3 (15.79%)	0 (0%)	1.000^a	-
Peripheral sensory neuropathy	18 (46.15%)	0 (0%)	9 (47.37%)	0 (0%)	0.931^b	-

Abbreviations: EA = electroacupuncture; ALT = alanine aminotransferase; AST = aspartate aminotransferase.

Significant differences are shown in bold.

Fisher’s exact test.

χ² test.