TABLE 1.

Top proteins used to predict age by CSF proteomics model. Features used by the elastic net to predict age were extracted along with their model weights. This table shows the full names, abbreviations, Entrez gene symbols and model weights of both the top 10 positively weighted (top) and top 10 negatively weighted (bottom) proteins ordered by model weight. The table also shows each protein's spearman correlation with age across the entire dataset. Values are listed where spearman correlation with age significance met a threshold of p < 0.0001. NS is listed if the protein did not correlate with age significantly.

Protein full name	Protein	Gene	Age correlation
CSF top 10 proteins positively correlated with age
Neurofilament heavy polypeptide	NFH	NEFH	0.64
Neurofilament light polypeptide	NFL	NEFL	0.62
Growth/differentiation factor 15	MIC‐1	GDF15	0.61
Spermatogenesis‐associated protein 9	SPAT9	SPATA9	0.59
Potassium voltage‐gated channel subfamily E regulatory beta subunit 5:Cytoplasmic domain	KCE1L:CD	KCNE5	0.57
Thrombospondin‐1	Thrombospondin‐1	THBS1	0.57
Myosin, light chain 9, regulatory	MYL9	MYL9	0.57
Coiled‐coil domain‐containing protein 80	URB	CCDC80	0.56
Left–right determination factor 2	Lefty‐A	LEFTY2	0.55
Activin A	Activin A	INHBA	0.54
CSF top 10 proteins negatively correlated with age
Sialidase‐1	NEUR1	NEU1	−0.43
Testis‐specific serine/threonine‐protein kinase 1	TSSK1	TSSK1B	−0.40
Procollagen‐lysine,2‐oxoglutarate 5‐dioxygenase 2	PLOD2	PLOD2	−0.38
Fibroblast growth factor 8 isoform B	FGF‐8B	FGF8	−0.37
RNA‐binding protein 39	RBM39	RBM39	−0.37
Prostate and testis expressed protein 1	PATE	PATE1	−0.36
Brain‐derived neurotrophic factor	BDNF	BDNF	−0.36
Coiled‐coil‐helix‐coiled‐coil‐helix domain‐containing protein 7	CHCH7	CHCHD7	−0.36
ATPase family AAA domain‐containing protein 1	ATAD1	ATAD1	−0.36
Glucocorticoid modulatory element‐binding protein 2	GMEB2	GMEB2	−0.35