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Schematic diagram of the therapeutic mechanisms of EE on cognitive impairment in AD. The therapeutic mechanisms of EE are: 1) attenuation of AD‐related pathologies, including Aβ accumulation, neuroinflammation, and neurodegeneration, 2) upregulation of the synaptic and neurotransmitter‐related proteome, and 3) modulation of neurotransmitter concentrations in the AD brain. Consequently, EE intervention alleviates cognitive impairment in AD.
