Fig. 2.

Differential DNA methylation of progesterone receptor in human myometrium. Differentially methylated regions identified at the PGR (progesterone receptor) gene in the human myometrium tissue groups (a–f). MeDIP-chip signals are shown as P values (−log10, left panel) and threshold peaks (−log10 ≥ 2.0, right panel). LOC101054525 is an antisense nonprotein coding RNA transcript (PGR-AS1) located within the PGR gene (Table 2). PGR-AS1 is transcribed at the genomic region adjacent to the transcriptional start site of the progesterone receptor isoform A (PR-A) gene in the opposite direction. Note that differentially (Fig. 1C and this figure) or constitutively methylated regions (Fig. 1B) are predominantly found outside of CpG islands but frequently within CpG island shores (2 kb flanking regions around the edges of CpG islands) and shelves (2kb flanking regions around the edges of CpG island shores). Red arrow = hypermethylation, blue arrow = hypomethylation.