Table. 2.
Differential methylation in the myometrial epigenome identified at the contraction-associated genes by MeDIP-chip.
| Symbol | Gene | Locus | CpG islands | Cytosine methylation | Differential methylation |
|---|---|---|---|---|---|
| PTGES/mPGES-1 | Prostaglandin E synthase | 9q34.3 | CpG-rich | Detected | Hypermethylated in (b) and (c) |
| PTGIS/PTGI | Prostaglandin I2 (prostacyclin) synthase | 20q13.13 | 5′ | Detected | Hypermethylated in (b) and (c) |
| PTGDR2 | Prostaglandin D2 receptor 2 (DP2) | 11q12-q13.3 | 5′ | Detected | Hypermethylated in (b) and (c)* |
| PTGS1/COX1 | Prostaglandin-endoperoxide synthase 1 (cyclooxygenase-1, COX-1) | 9q32-q33.3 | CpG-rich | Detected | Hypermethylated in (b) |
| PTGIR | Prostaglandin I2 (prostacyclin) receptor (IP) | 19q13.3 | CpG-rich | Detected | Hypermethylated in (b) |
| PTGFR | Prostaglandin F receptor (FP) | 1p31.1 | 5′ | Detected | Hypermethylated in (c)* |
| PTGDR | Prostaglandin D2 receptor (DP) | 14q22.1 | 5′ | Detected | Hypermethylated in (d), (e), and (f)* |
| PTGS2/COX2 | Prostaglandin-endoperoxide synthase 2 (cyclooxygenase-2, COX-2) | 1q25.2-q25.3 | 5′ | Detected | Hypomethylated in (b) and (c)* |
| PTGER3 | Prostaglandin E receptor 3 (EP3) | 1p31.2 | 5′ | Detected | Hypomethylated in (b) and (c)* |
| PGR/PR/NR3C3 | Progesterone receptor (isoforms A and B) | 11q22-q23 | 5′ | Detected | Hypomethylated in (b) and (c)* |
| AKR1C3/PGFS | Aldo-keto reductase 1, C3 (prostaglandin F synthase) | 10p15-p14 | None | Detected | Hypomethylated in (b) and (c) |
| OXTR/OT-R | Oxytocin receptor | 3p25 | 5′ | Detected | Hypomethylated in (b)* |
| ESR1 | Estrogen receptor 1 (ER alpha) | 6q25.1 | 5′ | Detected | Hypomethylated in (b) and (f) |
| PTGES3L | Prostaglandin E synthase 3 (cytosolic)-like | 17q21.31 | 5′ | Detected | No differential methylation |
| PTGER2 | Prostaglandin E receptor 2 (EP2) | 14q22 | 5′ | Detected | No differential methylation |
| PTGER4 | Prostaglandin E receptor 4 (EP4) | 5p13.1 | 5′ | Detected | No differential methylation |
| PTGFRN | Prostaglandin F2 receptor inhibitor | 1p13.1 | 5′ | Detected | No differential methylation |
| GJA1/CX43 | Gap junction protein, alpha 1, 43 kDa (Connexin 43) | 6q22.31 | None | Detected | No differential methylation |
| ESR2 | Estrogen receptor 2 (ER beta) | 14q23.2 | 5′ | Detected | No differential methylation |
| PTGES2/mPGES-2 | Prostaglandin E synthase 2 (PGES2) | 9q34.12 | 5′ | Not detected | Not applicable |
| PTGES3/cPGES | Prostaglandin E synthase 3 (cytosolic) | 12q13.13 | 5′ | Not detected | Not applicable |
| PTGER1 | Prostaglandin E receptor 1 (EP1) | 19p13.1 | CpG-rich | Not detected | Not applicable |
*
Differentially methylated regions located within CpG island shores or shelves.