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. 2024 Oct 18;132(10):107005. doi: 10.1289/EHP14378

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Figure 1A is a forest plot titled Lasso, plotting thiocarbamate herbicide prosulfocarb, azole fungicide difenoconazole, amide herbicide metolachlor, pyrethroid 3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarboxylic acid, organophosphate 3-methyl-4-nitrophenol, organophosphate diethylthiophosphate, organophosphate dimethyl thiophosphate, organochlorine pentachlorophenol, organochlorine beta-hexachlorocyclohexane, triazine herbicide prometryn, azole fungicide tebuconazole, azole fungicide flusilazole, and organochlorine beta-endosulfan (y-axis) across percentage difference, ranging from negative 10 to 20 in increments of 5. Figure 1B is a forest plot titled Multipollutant ordinary least squares, plotting thiocarbamate herbicide prosulfocarb, azole fungicide difenoconazole, amide herbicide metolachlor, pyrethroid 3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarboxylic acid, organophosphate 3-methyl-4-nitrophenol, organophosphate diethylthiophosphate, organophosphate dimethyl thiophosphate, organochlorine pentachlorophenol, organochlorine beta-hexachlorocyclohexane, triazine herbicide prometryn, azole fungicide tebuconazole, azole fungicide flusilazole, and organochlorine beta-endosulfan (y-axis) across percentage difference (95 percent confidence interval), ranging from negative 25 to 50 in increments of 25. — Percentage differences in hair tetraiodothyronine (T4) concentration per 2-SD increase in $log to the base 10$ -transformed pollutant (continuous variable; blue circle symbol) concentration or detect vs. nondetect (binary variable; dark blue square) in (A) the multipollutant lasso model or (B) the subsequent multipollutant OLS model on the pollutants stably selected by the lasso model among 196 healthy Chinese women of reproductive age. Models were adjusted for age, body mass index, and city. Symbols in (B) represent average percentage differences and lines represent 95% CIs. Numerical values are reported in Excel Tables S6 and S8. Note: 3Me4NP, 3-methyl-4-nitrophenol; AM, amide herbicide; AZ, azole fungicide; CI, confidence interval; $3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarboxylic acid$ , 3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarboxylic acid; DETP, diethylthiophosphate; DMP, dimethyl thiophosphate; HCH, hexachlorocyclohexane; Lasso, least absolute shrinkage and selection operator; OC, organochlorine; OLS, ordinary least squares; OP, organophosphate; PCP, pentachlorophenol; PY, pyrethroid; SD, standard deviation; TH, thiocarbamate herbicide; TR, triazine/triazone herbicide.