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. 2024 Oct 18;132(10):107005. doi: 10.1289/EHP14378

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Figure 2A is a forest plot titled Lasso, plotting urea herbicide 1-(3,4-dichlorophenyl)urea; acid herbicide 4-chloro-2-methylphenoxyacetic acid; acid herbicide 2,4-dichlorophenoxyacetic acid; neonicotinoid imidacloprid; pyrethroid trans-3-(2,2dichlorovinyl)-2,2-dimethylcyclopropane-carboxylic acid; organophosphate 3-methyl-4-nitrophenol; organophosphate dimethyl phosphate; organochlorine pentachlorophenol; organochlorine gamma-hexachlorocyclohexane; organochlorine beta-hexachlorocyclohexane; triazine herbicide atrazine; strobilurin fungicide pyraclostrobin; carbamate propoxur; organochlorine alpha-hexachlorocyclohexane (y-axis) across percentage difference, ranging from negative 4 to 8 in increments of 2 (x-axis). Figure 2B is a forest plot titled Multipollutant ordinary least squares, plotting urea herbicide 1-(3,4-dichlorophenyl)urea; acid herbicide 4-chloro-2-methylphenoxyacetic acid; acid herbicide 2,4-dichlorophenoxyacetic acid; neonicotinoid imidacloprid; pyrethroid trans-3-(2,2dichlorovinyl)-2,2-dimethylcyclopropane-carboxylic acid; organophosphate 3-methyl-4-nitrophenol; organophosphate dimethyl phosphate; organochlorine pentachlorophenol; organochlorine gamma-hexachlorocyclohexane; organochlorine beta-hexachlorocyclohexane; triazine herbicide atrazine; strobilurin fungicide pyraclostrobin; carbamate propoxur; organochlorine alpha-hexachlorocyclohexane (y-axis) across percentage difference (95 percent confidence interval), ranging from negative 20 to 20 in increments of 10 (x-axis). — Percentage differences in hair 3,3′,5-triiodothyronine (T3) concentration per 2-SD increase in $log to the base 10$ -transformed pollutant (continuous variable; blue circle symbol) concentration or detect vs. nondetect (binary variable; dark blue square) in (A) the multipollutant lasso model (B) the subsequent multipollutant OLS model on the pollutants stably selected by the lasso model among 196 healthy Chinese women of reproductive age. Models were adjusted for age, body mass index, and city. Symbols in (B) represent average percentage differences and lines represent 95% CIs. Numerical values are reported in Excel Tables S6 and S8. Note: 2,4-D, 2,4-dichlorophenoxyacetic acid; 3Me4NP, 3-methyl-4-nitrophenol; AC, acid herbicide; CA, carbamate; CI, confidence interval; $3-(2,2dichlorovinyl)-2,2-dimethylcyclopropane-carboxylic acid$ , trans-3-(2,2dichlorovinyl)-2,2-dimethylcyclopropane-carboxylic acid; DCPU, 1-(3,4-dichlorophenyl)urea; DMP, dimethyl phosphate; HCH, hexachlorocyclohexane; Lasso, least absolute shrinkage and selection operator; MCPA, 4-chloro-2-methylphenoxyacetic acid; NE, neonicotinoid; OC, organochlorine; OLS, ordinary least squares; OP, organophosphate; PCP, pentachlorophenol; PY, pyrethroid; SD, standard deviation; ST, strobilurin fungicide; TR, triazine/triazone herbicide; UR, urea herbicide.