Fig. 2. Fab117 binds to the interior surface of the dissociated SAT2/ZIM/7/83 pentamer. (a) Representative 2D class averages. (b) Final 3D reconstruction. (c, d) Close-up of the Fab117-SAT2/ZIM/7/83 complex density, viewed towards (c) the interior capsid surface and (d) from above the fivefold axis looking downward at the hydrophobic binding pocket. Density coloured by molecule: VP1 – blue, VP2 – turquoise, VP3 – orange and Fab117 CDR-H3 – purple.
