Longitudinal changes in QI values of patients with major depressive disorder after participating in the EGUIDE educational program. DQI, quality indicator of major depressive disorder; EGUIDE (+), patients treated by psychiatrists who participated in the EGUIDE project; non‐EGUIDE, patients treated by psychiatrists who have never participated in the EGUIDE project, (a) DQI‐2 – proportion of antidepressant monotherapy without other psychotropics, (b) DQI‐3 – proportion of no prescription of anxiolytics or hypnotics. Patients under the care of EGUIDE (+) psychiatrists were defined before participation (pre‐EGUIDE), at one year after participation (1 year), 2 years of participation (2 years) and 3 years of participation (3 years). Patients under the care of non‐EGUIDE psychiatrists were defined before starting the EGUIDE lecture (pre‐EGUIDE), at one year after EGUIDE (1‐year), 2 years after EGUIDE (2‐years) and 3 years after EGUIDE (3‐years). Logistic regression analysis was used to analyze the effect of the number of years since participation on QI values, adjusting for confounding factors, age, sex, and type of facilities. *P < 0.05, **P < 0.01, n.s., not significant.