Fig. 3.

Simple mediation diagram in YOAD; a, b, c, and c' are path coefficients representing unstandardized regression weights and standard errors (in parentheses). The c path coefficient represents the total effect of the ALPS‐index on CASI total scores. The c' path coefficient refers to the direct effect of the ALPS‐index on CASI total scores. All analyzed a, b, and c paths were significant, *P < 0.05, ***P < 0.001. ALPS, diffusion tensor imaging along the perivascular space; CASI, Cognitive Ability Screening Instrument. YOAD, young‐onset Alzheimer's disease.