Table 1.
Demographic data comparisons
| Diagnosis | Mean | SD | P value | |
|---|---|---|---|---|
| Female | CTL | 77 | 0.53 | |
| YOAD | 78 | |||
| Educational years | CTL | 12.47 | 3.63 | 3.96 × 10−8 |
| YOAD | 9.59 | 4.38 | ||
| Age at image study (year‐old) | CTL | 58.52 | 5.71 | 0.12 |
| YOAD | 60.15 | 3.67 | ||
| Mini‐Mental State Examination (30) | CTL | 28.01 | 1.80 | 1.22 × 10−30 |
| YOAD | 19.55 | 7.77 | ||
| CASI Total Score (100) | CTL | 92.41 | 5.21 | 2.18 × 10−24 |
| YOAD | 65.97 | 26.91 | ||
| Mental Manipulation (10) | CTL | 8.98 | 1.36 | 9.10 × 10−11 |
| YOAD | 5.88 | 3.74 | ||
| Attention (8) | CTL | 7.50 | 0.68 | 5.14 × 10−10 |
| YOAD | 6.07 | 2.08 | ||
| Orientation (18) | CTL | 17.61 | 1.03 | 1.62 × 10−15 |
| YOAD | 12.82 | 5.80 | ||
| Long term memory (10) | CTL | 9.89 | 0.46 | 3.38 × 10−8 |
| YOAD | 7.84 | 3.52 | ||
| Short term memory (12) | CTL | 10.86 | 1.38 | 2.65 × 10−24 |
| YOAD | 5.35 | 3.88 | ||
| Abstract thinking (12) | CTL | 10.12 | 1.68 | 1.08 × 10−10 |
| YOAD | 7.49 | 3.38 | ||
| Drawing ability (10) | CTL | 9.63 | 1.14 | 1.93 × 10−11 |
| YOAD | 7.50 | 3.17 | ||
| Verbal fluency (10) | CTL | 8.08 | 1.83 | 1.48 × 10−13 |
| YOAD | 5.09 | 3.11 | ||
| Language (10) | CTL | 9.75 | 0.48 | 8.50 × 10−9 |
| YOAD | 7.97 | 2.87 |
Note: Numbers in the parenthesis following cognitive tests indicate maximal score.
Abbreviation: YOAD: Young onset Alzheimer's disease (n = 130); CTL: age‐matched controls (n = 137).
CASI, Cognitive Ability Screening Instrument; SD, standard deviation.