Table 3.

Gray matter clusters related to MMSE and ALPS‐index in YOAD

Cluster	Cluster size	Anatomy & lateralization		X	Y	Z	T	P
I	3469	Cerebellum	R	15	−69	−54	5.15	<0.0001
II	1929	Amygdala	R	21	6	−16	4.72	<0.0001
		Hippocampus	R	32	−14	−12	4.12	<0.0001
III	2533	Cerebellum	L	−24	−70	−54	4.68	<0.0001
		Cerebellum crus	L	−36	−70	−46	3.99	<0.0001
IV	498	Superior frontal	L	−26	54	−8	4.66	<0.0001
V	1310	Thalamus	L	−20	−30	3	4.51	<0.0001
VI	1058	Thalamus	R	18	−30	3	4.5	<0.0001
VII	189	Superior temporal pole	L	−33	18	−28	4.09	<0.0001
VIII	302	Middle cingulate	R	14	16	39	3.92	<0.0001
IX	420	Middle frontal	R	27	52	−9	3.9	<0.0001
		Superior frontal	R	21	58	−2	3.84	<0.0001
X	351	Rectus	L	0	30	−15	3.88	<0.0001
XI	125	Insula	R	48	6	−3	3.77	<0.0001
XII	160	Insula	L	−40	9	0	3.7	<0.0001
XIII	130	Calcarine	R	9	−58	12	3.53	<0.0001

Note: Data adjusted estimated total intracranial volume.

X, Y, Z represent MNI coordinate; the anatomy is based on the AAL3 template. P uncorrected, with cluster size >100 voxels.

Abbreviation: ALPS, diffusion tensor imaging along the perivascular space; CTL, age‐matched controls; L: left; MMSE, Mini‐Mental State Examination; R, right; YOAD, Young onset Alzheimer's disease.