TABLE 2.
Risk of large for gestational age (LGA) in frozen embryo transfer cycles by associated in vitro fertilization demographics.
| Variable | LGA (n = 33,030) | Total (n = 181,592) | P value |
|---|---|---|---|
| Day of cryopreservation | |||
| Day 2 (Reference) | 66 (13.7%) | 481 | |
| Day 3 | 410 (14.4%) | 2,851 | |
| Day 4 | 194 (15.0%) | 1,294 | |
| Day 5 | 21,930 (18.2%) | 120,568 | |
| Day 6 | 10,134 (18.5%) | 54,829 | |
| Day 7 | 296 (18.9%) | 1,569 | < .001 |
| Diagnosis | |||
| Male | |||
| Yes | 12,178 (18.4%) | 66,090 | |
| No | 20,852 (18.1% | 115,502 | .047a |
| Endometriosis | |||
| Yes | 2,731 (19.5%) | 14,026 | |
| No | 30,299 (18.1%) | 167,566 | <.001a |
| PCOS | |||
| Yes | 11,619 (18.6%) | 62,459 | |
| No | 21,411 (18.0% | 119,113 | <.001a |
| DOR | |||
| Yes | 4,982 (17.2%) | 28,940 | |
| No | 28,048 (18.4%) | 152,652 | <.001a |
| Tubal ligation | |||
| Yes | 4,118 (19.3%) | 21,329 | |
| No | 28,912 (18.0%) | 160,263 | <.001a |
| Uterine | |||
| Yes | 1,953 (19.2%) | 10,193 | |
| No | 31,077 (18.1% | 171,399 | .009a |
| Unexplained | |||
| Yes | 4,407 (16.8%) | 26,296 | |
| No | 28,623 (18.4%) | 155,296 | <.001a |
| RPL | |||
| Yes | 1,210 (18.5%) | 6,535 | |
| No | 31,820 (18.2%) | 175,057 | .486a |
| Other | |||
| Yes | 7,707 (17.9%) | 43,143 | |
| No | 25,323 (18.3%) | 138,449 | .045a |
| Maximum FSH (IU/L) | |||
| <4 | 703 (17.2%) | 4,092 | |
| 4–>10 (Reference) | 18,084 (18.3%) | 98,769 | |
| ≥10 | 3,358 (16.1%) | 20,861 | |
| Missing | 10,885 (18.8%) | 57,870 | < .001 |
| PGT-A | |||
| No (reference) | 17,151 (19.3%) | 88,755 | |
| Yes (all) | 11,535 (17.0%) | 67,976 | |
| Yes (some) | 4,261 (17.4%) | 24,432 | |
| Unknown/missing | 71 (19.0%) | 373 | < .001 |
| Oocytes retrieved | |||
| 0–4 (Reference) | 956 (17.2%) | 5,548 | |
| 5–9 | 4,562 (17.5%) | 26,143 | |
| 10–19 | 14,900 (18.2%) | 81,731 | |
| 20–29 | 8,424 (18.3%) | 45,918 | |
| ≥30 | 4,086 (18.8%) | 21,738 | |
| Missing | 102 (19.8%) | 514 | < .001 |
| EMS (mm [±SD]) | |||
| 0–<7 | 1,056 (17.7%) | 5,975 | |
| 7–<12 (Reference) | 16,370 (17.9%) | 91,555 | |
| ≥12 | 3,853 (20.1%) | 19,158 | |
| Missing | 11,717 (18.1%) | 64,753 | < .001 |
| Number transferred | |||
| 1 (Reference) | 26,596 (18.1%) | 147,054 | |
| 2 | 6,127 (18.7%) | 32,845 | |
| 3 | 268 (18.4%) | 1,456 | |
| Missing | 39 (16.5%) | 237 | .096 |
| Embryo Grade | |||
| Good (Reference) | 16,298 (18.1%) | 90,051 | |
| Fair | 5,278 (19.1%) | 27,590 | |
| Poor | 354 (19.7%) | 1,799 | |
| Missing | 11,100 (17.7%) | 62,152 | < .001 |
Notes: Data presented as number and % of cohort total(s).
DOR = diminished ovarian reserve; EMS = endometrial stripe measurement; FSH = follicle-stimulating hormone; PCOS = polycystic ovary syndrome; PGT = preimplantation genetic testing for aneuploidy; RPL = recurrent pregnancy loss.
a
Chi-square test, comparing those with a diagnosis to no diagnosis.