Table 1. Comparison of mitoXplorer heatmaps for transcriptomics and proteomics analyses (related to Figure 6—figure supplement 4, Figure 7—figure supplement 4).

Regulation in KIC muscle versus control	Genes/proteins	Pathways
Upregulated both in transcriptomics and proteomics analyses	Sirt2	Mitochondrial signaling
Downregulated both in transcriptomics and proteomics analyses	Eno3 Pgam2 Mrpl19 Dlst Pdp1 Dnaja1 Cyb5b	Glycolysis Glycolysis Translation Tricarboxylic acid cycle Pyruvate metabolism Protein stability and degradation Metabolism of vitamins and cofactors
Upregulated in transcriptomics and downregulated in proteomics analyses	Pcca Gpx4 Gstp1 Aldh7a1 Aldh1l1	Amino acid metabolism ROS defense ROS defense Pyruvate metabolism Folate and pterin metabolism
Downregulated in transcriptomics and upregulated in proteomics analyses	Mrpl45 Coq3 Nme1	Translation Ubiquinone biosynthesis Nucleotide metabolism