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. 2024 Oct 7;66(4):ezae364. doi: 10.1093/ejcts/ezae364

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© The Author(s) 2024. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6: — Colchicine reduced NETs release by suppressing PAD-4. (A) Immunofluorescence (scale bars, 20 μm) assessed PAD-4 levels in CPB, I/R + saline and I/R + COL groups (n = 6). (B) Fluorescence intensity of PAD-4 was semi-quantitatively analysed. (C and D) Western blot measured PAD-4 expression in CPB, I/R + saline and I/R + COL groups. (E) HE staining assessed inflammatory cell infiltration in I/R + COL and I/R + CI-am groups. **P < 0.01, ***P < 0.001. Data are expressed as mean (SD). CI-am: CI-amidine; COL: colchicine; CPB: cardiopulmonary bypass; HE: haematoxylin and eosin; I/R: ischaemia–reperfusion; PAD-4: peptidylarginine deiminase 4; SD: standard deviation.