Electrospinning |
Polymer solution (fiber + solvent), spinneret, syringe, syringe pump, collector |
Properties of polymer solution (Mw of polymer, %w/v of solution), distance between the collector and the needle tip, nozzle diameter, environmental condition (ambient temperature and relative humidity), applied voltage |
Ability to create multiple fiber assemblies. Most flexible method. Enables adjustment tailored to certain application and great mechanical strength. It has control over porosity, pore size distribution, and scaffold architecture. Large specific area and pore volume |
Poor cell infiltration and migration due to the close packing of scaffold fibers, toxicity of the residual solvent, low mechanical strength of scaffolds for load-bearing applications |
Electrostatic flocking |
Substrate (vascular graft, cardiac patches, stents), adhesives, flock fibers |
Fiber density, flock time, Fiber length, applied voltage |
Exceptional surface area to volume ratio, efficient cell cultivation, great porosity, strong mechanical characteristic |
Stringent electrical conductivity requirement, inability to produce individual flock fibers |
Weaving |
Warp, weft |
Weave used, thread spacing, material used, warp and weft density, yarn fineness, interlacing law, quantity of warps and weft per square inch |
Less mechanically demanding than others, higher strength, greater stability than knitted and braided fibers |
Manually made, smaller pores and less porous than knitted fabrics, lower flexibility than knitted fabrics |
Knitting |
Warp, weft |
Density of needle (gauge), type and size of yarn, tension applied, knitting technique, stitch pattern |
Greater pores, superior softness, elasticity and bursting qualities than weaving and braiding, higher porosity and more favorable to cell growth than woven fabrics. |
Not good for cell seedling, challenging to modify in different directions |
Good for creation of load-bearing tissue due to its capacity to stretch |
Braiding |
Three or more yarn |
Fiber material, braiding angle, fiber density, layer count |
Load-bearing capacity, strong tensile strength and mechanical flexibility, damage tolerance and resistance in bending, torsion, and traction, improved abrasion resistance |
Minimal porosity |