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. 2024 Sep 30;42:100878. doi: 10.1016/j.bbih.2024.100878

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Published by Elsevier Inc.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 2 — Effects of CORT, DFP and LPS on brain microstructural integrity. A: 3D rat brain showing ROIs and a representative GFA map. B: Group-level comparison of GFA in each ROI comparing three exposure groups to saline control. Open circles indicate individual data points. C: Quantitative analysis of total activated glia (astrocytes and microglia) to total glia ratio among three exposure groups. Open circles indicate individual data points. D: Correlation between GFA and glial cell count ratio in left dorsal hippocampus. E: Representative image of Iba1+ microglia (green) and GFAP + astrocytes (red) in the left dorsal hippocampus. F: Representative images of activated (top left) and homeostatic microglia (bottom left), reactive (top right) and homeostatic (bottom right) astrocytes. P ≤ 0.05 compared to the CORT(∗) or CORT + LPS(#) group. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)