TABLE 1.

The cardioprotective role of different cannabinoids.

Compound	Dose, duration, and route of administration	Mechanisms of protection	Reference
AM1241	20 mg/kg, i.p. for 7 days to C57BL/6 male mice	↑Akt/Nrf2/HO‐1	[29]
AM1241	20 mg/kg, i.p. for 28 days to mice	↓ROS, MDA, ↑p‐Akt ↑p‐Erk, ↑p‐Stat3, ↓TGF‐β1, PDGF	[30]
AM1241	20 mg/kg, i.p. injected for 7 days to C57BL/6 mice	↓MDA, TNF‐α, IL‐6, ↑c‐kit+, Runx1+ ↑Nrf2, HO‐1	[32]
AM1241	20 mg/kg, i.p. for 21 days to C57BL/6 mice	↓TGF‐β, collagen I, collagen III, MMP	[31]
EHP101	5, 10, and 20 mg/kg, p.o. for 2 weeks to C57‐BL/6 mice	↓NFAT, ↓ERK1 + 2, ↓IL1β, ↓IL6, ↓Col1A2, ↓CCL2, ↓CD3+, F4/80+ cells, Cdk1, Top2a, Ki67	[33]
JWH133	3 mg/kg, i.p., single injection to CB2−/− mice 0.5 μM to fibroblasts	↓TNF‐α, ↓α‐SMA ↑MMP‐2	[34]
AM1241, JWH133	AM 1241 (5 μM) and JWH‐133 (1 μM) 30 min prior to quetiapine‐to‐myocardial HL‐1 cells	↓p‐MLKL, ↓Inflammation ↓fibrosis	[35]
2‐Arachidonoylglycerol	10 μg/kg for 4 weeks to C57BL/6 mice	↓TGF‐β1 ↓p‐Smad2/3	[36]
HU910	10 mg/kg, i.p. for 14 days to C57BL/6J mice	↓CD45+ cells, ↓ MIP1α, IL1α, and TLR4, ↓E‐selectin, VCAM‐1, ICAM‐1, ↓COX1,2, ↓3‐NT, and MDA	[37]