TABLE 3.

The protective role of different cannabinoids in the lungs.

Compound	Dose, duration, and route of administration	Mechanisms of protection	Reference
Cannabidiol	5 or 10 mg/kg i.p. for 8 days to Balb/c mice	↓Collagen, ↓IL‐4, IL‐5, IL‐13	[63]
WIN 55212–2	0.2–1 mg/kg, i.p. for 28 days to C57BL/6 mice	↓TGF‐β, α‐SMA, PDGFRa, fibronectin, and collagen I, ↓TNF‐ α and IL‐6, ↑CD206, CD163 ↑IL‐10 ↓CCR7 + cells (M1)	[64]
YX‐2102	25 mg/kg, i.p. for 21 days to Sprague–Dawley rats	↓fibronectin and α‐SMA, ↑E‐cadherin ↓myeloperoxidase, CD68, ↓IL‐6, MCP‐1, IL‐1β, ↑CD206	[65]
JWH 133	1 mg/kg, i.p. for 14 days to Swiss mice	↓Hyperemia ↓hemorrhage ↓leucocytes infiltration ↓hyperplasia ↓collagen	[66]
JWH133	2.5 mg/kg, i.p. for 21 days to C57BL/6 mice	↓Hydroxyproline ↓collagen I, ↓α‐SMA, ↓TGF‐β/Smad, ↓PDGF	[67]
AM1241	1, 3 mg/kg, i.p. for 28 days to Wistar rats.	↓IL‐6 and TNF‐α ↓MDA, ↑GSH	[68]
EHP‐101	5, 10, and 25 mg/kg, p.o. for 4 weeks to BALB/c mice	↑vessels perimeter ↓myofibroblast ↓collagen	[69]
Pirfenidone	300 mg/kg, p.o. for 15 days to C57BL/6 mice	↓collagen, ↓TNF‐α, IL‐1β, and IL‐6	[70]
Lenabasum	0.1, 0.3, 1, 3, 10, and 30 μM to monocyte‐derived macrophages	↓IL‐8, TNF‐α, and IL‐13	[71]
Ajulemic acid	1 mg or 5 mg/kg, p.o. for 21 days to DBA/2 mice	↓HO‐proline, ↓TGF‐β1, ↑PPAR‐γ, ↓pSMAD2/3, ↓CTGF, ↓α‐SMA	[72]