Table 6.
Clinical and laboratory factors associated with very severe anaemia in SCD during steady-state.
| Variable | Univariable |
Multivariate (n = 13,512) |
||
|---|---|---|---|---|
| OR (95% CI) | p-value | OR (95% CI) | p-value | |
| Log (age), (n = 14,354) | 1.00 (0.86–1.17) | 0.987 | ||
| Sex (n = 14,371) | 1.20 (0.90–1.61) | 0.220 | ||
| Pulse (n = 14,155)b | 1.07 (1.04–1.11) | <0.001 | 1.05 (1.00–1.01) | 0.075 |
| Hepatomegaly (n = 12,262) | 1.59 (0.83–3.05) | 0.161 | ||
| Enlarged spleen (n = 13,996) | 2.53 (1.93–3.32) | <0.001 | 1.68 (1.25–2.25) | 0.001 |
| Laboratory features | ||||
| MCV (n = 14,267) | 1.06 (1.05–1.07) | <0.001 | 1.08 (1.066–1.10) | <0.001 |
| MCHC (n = 14,287) | 0.75 (0.71–0.79) | <0.001 | 0.80 (0.75–0.86) | <0.001 |
| RDW (n = 14,324) | 1.20 (1.17–1.23) | <0.001 | 1.22 (1.19–1.26) | <0.001 |
| Reticulocytes (n = 5790)a | 1.06 (1.03–1.08) | <0.001 | ||
| WBC (n = 14,325)a | 1.06 (1.05–1.08) | <0.001 | ||
| Platelet count (n = 14,257) | 0.95 (0.94–0.96) | <0.001 | 0.96 (0.96–0.97) | <0.001 |
| AST (n = 14,257)a,c | 1.003 (0.990–1.016) | 0.643 | ||
| LDH (n = 2328)a,c | 1.01 (1.01–1.02) | <0.001 | ||
a
Variables were not significant in the multivariate model.
b
Scaled by 10 (i.e. RBC ∗ 10).
c
Scaled by 0.1 (i.e. LDH ∗ 0.1; Platelet count∗ 0.1).