Fig. 1.

The CHARON algorithm. The different ataxias are marked in bold. The blue boxes indicate the additional neuroradiological findings characteristic for each entity, while typical clinical and laboratory data are shown in the red and green boxes, respectively. CHARON: Characterization of Hereditary Ataxias Relying On Neuroimaging; CTX: Cerebrotendinous Xanthomatosis; AOA: Ataxia with Oculomotor Apraxia; SPG7: Spastic Paraplegia Type 7; SCAR10: Autosomal Recessive Spinocerebellar Ataxia Type 10; SCA: Spinocerebellar Ataxia; ARSACS: Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay; FXTAS: Fragile X-associated Tremor/Ataxia Syndrome; FRDA: Friedreich’s Ataxia; AT: Ataxia-Telangiectasia; AVED: Ataxia with isolated Vitamin E Deficiency; AFP: Alpha-Fetoprotein; CoQ10: Coenzyme Q10