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Pathway inhibitor LY294002 reversed the stimulation of PI3K/AKT/mTOR pathway and the proliferation, migration, and invasion of GC cells induced by ACTL8 overexpression. A After LY294002 (5 μM) was added to MKN45 cells, the expressions of related proteins in the PI3K/AKT/mTOR pathway were decreased. B The CCK8 results showed that the proliferation ability of GC cells was weakened. C The transwell results showed that the migration and invasion abilities of GC cells were decreased
