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. 2024 Oct 18;14:24482. doi: 10.1038/s41598-024-75983-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Experiment flowchart. After obtaining individual sera from experimental participants, pooled sera were prepared, and serum proteins were digested into peptides for mass spectrometry. Protein identification and biomarker discovery were performed using DDA data from pooled serum and DIA data from individual serum. MRM validation was subsequently performed on the selected marker candidates.