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. 2024 Oct 18;14:24512. doi: 10.1038/s41598-024-75514-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Confirmatory testing results for protein S autoantibodies. Scatterplot (a) shows protein S concentration and autoantibody response in different subgroups as stratified by the legend as well as the correlation curve for subjects with > 500 AU response to protein S in the bead-based assay. Correlation coefficient (Pearson r) and p value refers to all subjects with response exceeding 500 AUs. Protein S activity results in relation with protein S concentrations (b) reveals three patients with reduced protein S activity (< 55% of pooled plasma) and one patient with increased activity. Note: one patient with protein S autoantibody positivity did not undergo confirmatory analyses due to unavailability of sample. Abbreviations: AU: arbitrary unit, aAb: autoantibody.