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. 2024 Oct 18;25:364. doi: 10.1186/s12882-024-03798-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 5 — Intersecting genes identified by CKD GWAS studies and those that are transcriptionally regulated in CKD. (a) The list of up- and down- regulated genes in glomerular and tubular area, respectively. The common genes are indicated in different colors. (b) PPI diagram of the regulated GWAS CKD genes, highlighting the module of collagen genes. Only the interactions of two genes were approved with experiments, derived from databases, co-expressed were considered in this analysis, as well the protein homologies. (c) KEGG enriched pathways of these genes showing AGE-RAGE, ECM and cell senescence. (d) 62% of the CKD-regulated GWAS genes overlap with kidney-specific eQTL-associated eGenes [41, 42]