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. 2024 Oct 6;18(5):183–198. doi: 10.1049/syb2.12099

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© 2024 The Author(s). IET Systems Biology published by John Wiley & Sons Ltd on behalf of The Institution of Engineering and Technology.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Epithelial cell cluster. (a–b) t‐SNE plot of 6167 epithelial cells, colour‐coded by their associated cluster or sample type. (c) Differences in pathway activities scored per cell by Gene set variation analysis (GSVA) analysis between normal (non‐PTC) and PTC epithelial cells. T‐values from a linear model are shown. (d) Boxplots show activity scores for 5 selected signalling pathways, stratified by normal (non‐PTC) or PTC epithelial clusters (blue and orange). PTC: papillary thyroid carcinoma; and GSVA: Gene set variation analysis.