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Summarized illustration of FLT3 targeting CAR T-Cells (A) FLT3 CAR T-cell targeting FLT3 antigen; (B) FLT3L CAR T-Cell is a second-generation CAR T cells where the extracellular domain is the FLT3 ligand (FL) while 4–1BB and CD3ζ are the intracellular signal domains; (C) Bispecific FLT3 and WT-1 CAR T-cell that target the FLT3-ITD mutation and WT-1 mutation which has been demonstrated to be associated with FLT3-ITD mutations.
