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Summarized illustration of TCR engineered T cell approaches (A) targeting FLT3 neoantigen peptides; (B) Specific peptide enhanced affinity receptors (SPEARs) technology designed to modify the hypervariable complementary determining regions that bind to the displayed neoantigen peptide while simultaneously displaying no alloreactivity; (C) Hybrid murine-human TCR for better pairing and TCR/CD3 stability.
