Fig. 2.

Local genetic correlations between iron and NDD or CVD. Chromosomal visualization (created using PhenoGram⁷⁸) of significantly correlated regions between iron and the 11 neurodegenerative or cardiovascular traits tested as listed in Supplementary Table 1 (a). Illustration of selected significant shared regional correlations on chromosome 6 (either just upstream or within the major histocompatibility complex) between serum iron and lipid traits tested (b). **Significant local correlation after Bonferroni correction; s: p-value < 0.05 but not significant at the Bonferroni correction threshold; ns non-significant (p-value > 0.05), AD Alzheimer’s disease, PD Parkinson’s disease, ALS amyotrophic lateral sclerosis, CAD coronary artery disease, HF heart failure, TC total cholesterol, TG triglycerides, HDL high-density lipoprotein cholesterol, LDL low-density lipoprotein cholesterol, nonHDL non-high-density lipoprotein cholesterol.